To summarize, the adverse and pleasurable experiences a smoker has in response to the nicotine in a cigar depend both on dosage and experience. In most cases, when an inexperienced cigar smoker tries a cigar with high nicotine content, like a La Flor Dominicana Double Ligero or Opus X, the effects in the vestibular system and dopamine system will be very strong but the adverse vestibular effects such as nausea and dizziness will completely mask the pleasurable effects. That is why cigar reviewers frequently recommend that only experienced smokers try stronger cigars. Without the nicotine tolerance, it is likely smoking one of these cigars will be highly un-enjoyable, thus negatively affecting the results of the review.
After an individual has more experience with smoking cigars, tolerance will begin to occur whereby the nicotine receptors will produce less of a response in the brain for a given dosage. This will mean that the adverse effects will be much less intense, allowing the pleasurable effects to be unmasked. Furthermore, as a result of increasing the number of dopamine receptors in the brain (up-regulation), the pleasurable effects may become even stronger with repeated exposure.
* Note: This may not always be the case since manufacturers will often use different tobacco blends for the different vitolas in a particular cigar line.
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